Rat modeling and uric acid sustainability in hyperuricemic rats caused by potassium – oxonate

Abstract

Hyperuricaemia is an important risk factor of CKD , metabolic syndrome and cardiovascular disease. We aimed to assess that for how much time uric acid levels sustains in wistar rats. A hyperuricemia mouse model was to be established by potassium oxonate (PO) administered by oral gavage and by intraperitoneal injections. In hyperuricemia rats, serum uric acid levels
increased but not significantly after oral administration for 7 days but administering PO intraperitoneally serum uric acid levels increased significantly after 1 hour but again returned within normal range after 2 hours. This paper presents method suitable for experimental hyperuricemia mouse model and shows the time feature of uric acid sustainability